5A81

Crystal structure of human ATAD2 bromodomain in complex with 8-(3R,4R) -3-(cyclohexylmethoxy)piperidin-4-yl-amino-3-methyl-1,2-dihydro-1,7- naphthyridin-2-one

5A81 の概要

• エントリーDOI: 10.2210/pdb5a81/pdb
• 関連するPDBエントリー: 5A82 5A83 5A85
• 分子名称: ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 2, 1,2-ETHANEDIOL, (3R,4R)-3-(cyclohexylmethoxy)piperidin-4-yl]amino}-3-methyl-1,2-dihydro-1,7-naphthyridin-2-one, ... (5 entities in total)
• 機能のキーワード: hydrolase, inhibitor, atad2, bromodomain, epigenetics, atpase family aaa domain-containing protein 2
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus : Q6PL18
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16140.26

構造登録者

Chung, C.,Bamborough, P.,Demont, E. (登録日: 2015-07-11, 公開日: 2015-08-12, 最終更新日: 2024-05-08)

• 主引用文献: Bamborough, P.,Chung, C.,Furze, R.C.,Grandi, P.,Michon, A.,Sheppard, R.J.,Barnett, H.,Diallo, H.,Dixon, D.P.,Douault, C.,Jones, E.J.,Karamshi, B.,Mitchell, D.J.,Prinjha, R.K.,Rau, C.,Watson, R.J.,Werner, T.,Demont, E.H.; Structure-Based Optimization of Naphthyridones Into Potent Atad2 Bromodomain Inhibitors.; J.Med.Chem., 58:6151-, 2015; PubMed: 26230603; DOI: 10.1021/ACS.JMEDCHEM.5B00773

実験手法

X-RAY DIFFRACTION (2.03 Å)