5A7W
Crystal structure of human JMJD2A in complex with compound 35
Summary for 5A7W
Entry DOI | 10.2210/pdb5a7w/pdb |
Related | 5A7N 5A7O 5A7P 5A7Q 5A7S 5A80 |
Descriptor | LYSINE-SPECIFIC DEMETHYLASE 4A, SULFATE ION, 2-[5-[(4-hydroxyphenyl)carbonylamino]-2-oxidanyl-phenyl]pyridine-4-carboxylic acid, ... (9 entities in total) |
Functional Keywords | oxidoreductase, kdm4a |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Nucleus : O75164 O75164 |
Total number of polymer chains | 2 |
Total formula weight | 90253.61 |
Authors | Nowak, R.,Velupillai, S.,Krojer, T.,Gileadi, C.,Johansson, C.,Korczynska, M.,Le, D.D.,Younger, N.,Gregori-Puigjane, E.,Tumber, A.,Iwasa, E.,Pollock, S.B.,Ortiz Torres, I.,Kopec, J.,Tallant, C.,Froese, S.,von Delft, F.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.,Shoichet, B.K.,Fujimori, D.G.,Oppermann, U. (deposition date: 2015-07-10, release date: 2016-01-13, Last modification date: 2024-01-10) |
Primary citation | Korczynska, M.,Le, D.D.,Younger, N.,Gregori-Puigjane, E.,Tumber, A.,Krojer, T.,Velupillai, S.,Gileadi, C.,Nowak, R.P.,Iwasa, E.,Pollock, S.B.,Ortiz Torres, I.,Oppermann, U.,Shoichet, B.K.,Fujimori, D.G. Docking and Linking of Fragments to Discover Jumonji Histone Demethylase Inhibitors. J.Med.Chem., 59:1580-, 2016 Cited by PubMed: 26699912DOI: 10.1021/ACS.JMEDCHEM.5B01527 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.27 Å) |
Structure validation
Download full validation report