5A6H

Synthesis, carbonic anhydrase inhibition and protein X-ray structure of the unusual natural product primary sulfonamide Psammaplin C

5A6H の概要

• エントリーDOI: 10.2210/pdb5a6h/pdb
• 分子名称: CARBONIC ANHYDRASE 2, ZINC ION, DIMETHYL SULFOXIDE, ... (5 entities in total)
• 機能のキーワード: lyase, carbonic anhydrase inhibitor, natural product
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30573.25

構造登録者

Mujumdar, P.,Supuran, C.T.,Peat, T.S.,Poulsen, S. (登録日: 2015-06-26, 公開日: 2016-05-25, 最終更新日: 2024-01-10)

• 主引用文献: Mujumdar, P.,Teruya, K.,Tonissen, K.F.,Vullo, D.,Supuran, C.T.,Peat, T.S.,Poulsen, S.; An Unusual Natural Product Primary Sulfonamide: Synthesis, Carbonic Anhydrase Inhibition and Protein X-Ray Structures of Psammaplin C.; J.Med.Chem., 59:5462-, 2016; PubMed: 27172398; DOI: 10.1021/ACS.JMEDCHEM.6B00443

実験手法

X-RAY DIFFRACTION (1.57 Å)