5A5S
NN-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 5-5-methoxypyridin-3-yl-3- methyl-8-piperidin-4-ylamino-1,2-dihydro-1,7-naphthyridin-2-one
Summary for 5A5S
Entry DOI | 10.2210/pdb5a5s/pdb |
Related | 5A5N 5A5O 5A5P 5A5Q 5A5R |
Descriptor | BROMODOMAIN-CONTAINING PROTEIN 4, 1,2-ETHANEDIOL, 5-(5-methoxypyridin-3-yl)-3-methyl-8-[(piperidin-4-yl)amino]-1,2-dihydro-1,7-naphthyridin-2-one, ... (4 entities in total) |
Functional Keywords | hydrolase, inhibitor, histone, epigenetic reader, bromodomain, brd4, bromodomain containing protein 4, antagonist |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15527.93 |
Authors | Chung, C.,Bamborough, P.,Demont, E. (deposition date: 2015-06-20, release date: 2015-07-22, Last modification date: 2024-05-08) |
Primary citation | Demont, E.H.,Chung, C.,Furze, R.C.,Grandi, P.,Michon, A.,Wellaway, C.,Barrett, N.,Bridges, A.M.,Craggs, P.D.,Diallo, H.,Dixon, D.P.,Douault, C.,Emmons, A.J.,Jones, E.J.,Karamshi, B.V.,Locke, K.,Mitchell, D.J.,Mouzon, B.H.,Prinjha, R.K.,Roberts, A.D.,Sheppard, R.J.,Watson, R.J.,Bamborough, P. Fragment-Based Discovery of Low-Micromolar Atad2 Bromodomain Inhibitors. J.Med.Chem., 58:5649-, 2015 Cited by PubMed: 26155854DOI: 10.1021/ACS.JMEDCHEM.5B00772 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.36 Å) |
Structure validation
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