5A27
Leishmania major N-myristoyltransferase in complex with a chlorophenyl 1,2,4-oxadiazole inhibitor.
Summary for 5A27
Entry DOI | 10.2210/pdb5a27/pdb |
Related | 5A28 |
Descriptor | GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, TETRADECANOYL-COA, 5-chloranyl-N-[2-(3-methoxyphenyl)ethanimidoyl]-2-piperidin-4-yloxy-benzamide, ... (5 entities in total) |
Functional Keywords | transferase, myristoylation, drug design |
Biological source | LEISHMANIA MAJOR |
Total number of polymer chains | 1 |
Total formula weight | 48914.21 |
Authors | Rackham, M.D.,Yu, Z.,Brannigan, J.A.,Heal, W.P.,Paape, D.,Barker, K.V.,Wilkinson, A.J.,Smith, D.F.,Tate, E.W.,Leatherbarrow, R.J. (deposition date: 2015-05-15, release date: 2016-03-23, Last modification date: 2024-05-08) |
Primary citation | Rackham, M.D.,Yu, Z.,Brannigan, J.A.,Heal, W.P.,Paape, D.,Barker, K.V.,Wilkinson, A.J.,Smith, D.F.,Leatherbarrow, R.J.,Tate, E.W. Discovery of High Affinity Inhibitors of Leishmania Donovani N-Myristoyltransferase. Medchemcomm, 6:1761-, 2015 Cited by PubMed: 26962429DOI: 10.1039/C5MD00241A PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.37 Å) |
Structure validation
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