5A14
Human CDK2 with type II inhibitor
Summary for 5A14
Entry DOI | 10.2210/pdb5a14/pdb |
Descriptor | CYCLIN-DEPENDENT KINASE 2, 1-[4-(2-azanylpyrimidin-4-yl)oxyphenyl]-3-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]urea (3 entities in total) |
Functional Keywords | transferase, cdk2, cyclin, kinase, type ii, inhibitor |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 35005.54 |
Authors | Alexander, L.T.,Elkins, J.M.,Kopec, J.,Fedorov, O.,Savitsky, P.A.,Moebitz, H.,Cowan-Jacob, S.W.,Szklarz, M.,Pike, A.C.W.,Carpenter, E.P.,Krojer, T.,Bountra, C.,Edwards, A.M.,Knapp, S. (deposition date: 2015-04-27, release date: 2015-07-22, Last modification date: 2019-10-23) |
Primary citation | Alexander, L.T.,Mobitz, H.,Drueckes, P.,Savitsky, P.,Fedorov, O.,Elkins, J.M.,Deane, C.M.,Cowan-Jacob, S.W.,Knapp, S. Type II Inhibitors Targeting Cdk2. Acs Chem.Biol., 10:2116-, 2015 Cited by PubMed: 26158339DOI: 10.1021/ACSCHEMBIO.5B00398 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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