5A0B

Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor

5A0B の概要

• エントリーDOI: 10.2210/pdb5a0b/pdb
• 関連するPDBエントリー: 5A09 5A0A 5A0C
• 分子名称: NEUTROPHIL ELASTASE, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: trypsin family fold, protease, hydrolase, hydrolase- inhibitor complex
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24903.60

構造登録者

vonNussbaum, F.,Li, V.M.-J.,Allerheiligen, S.,Anlauf, S.,Baerfacker, L.,Bechem, M.,Delbeck, M.,Fitzgerald, M.F.,Gerisch, M.,Gielen-Haertwig, H.,Haning, H.,Karthaus, D.,Lang, D.,Lustig, K.,Meibom, D.,Mittendorf, J.,Rosentreter, U.,Schaefer, M.,Schaefer, S.,Schamberger, J.,Telan, L.A.,Tersteegen, A. (登録日: 2015-04-17, 公開日: 2015-08-19, 最終更新日: 2020-07-29)

• 主引用文献: von Nussbaum, F.,Li, V.M.,Allerheiligen, S.,Anlauf, S.,Barfacker, L.,Bechem, M.,Delbeck, M.,Fitzgerald, M.F.,Gerisch, M.,Gielen-Haertwig, H.,Haning, H.,Karthaus, D.,Lang, D.,Lustig, K.,Meibom, D.,Mittendorf, J.,Rosentreter, U.,Schafer, M.,Schafer, S.,Schamberger, J.,Telan, L.A.,Tersteegen, A.; Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases.; ChemMedChem, 10:1163-1173, 2015; PubMed: 26083237; DOI: 10.1002/cmdc.201500131

実験手法

X-RAY DIFFRACTION (2.23 Å)