5ZSJ
Crystal structure of monkey TLR7 in complex with GS9620
Summary for 5ZSJ
Entry DOI | 10.2210/pdb5zsj/pdb |
Descriptor | Toll-like receptor 7, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-azanyl-2-butoxy-8-[[3-(pyrrolidin-1-ylmethyl)phenyl]methyl]-5,7-dihydropteridin-6-one, ... (6 entities in total) |
Functional Keywords | innate immunity toll-like receptors, immune system |
Biological source | Macaca mulatta (Rhesus macaque) |
Total number of polymer chains | 2 |
Total formula weight | 194872.21 |
Authors | Zhang, Z.,Ohto, U.,Shimizu, T. (deposition date: 2018-04-28, release date: 2019-01-30, Last modification date: 2024-03-13) |
Primary citation | Zhang, Z.,Ohto, U.,Shibata, T.,Taoka, M.,Yamauchi, Y.,Sato, R.,Shukla, N.M.,David, S.A.,Isobe, T.,Miyake, K.,Shimizu, T. Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands. Cell Rep, 25:3371-3381.e5, 2018 Cited by PubMed: 30566863DOI: 10.1016/j.celrep.2018.11.081 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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