5Z9C
Solution NMR structures of BRD4 first bromodomain with small compound MMQO
Summary for 5Z9C
| Entry DOI | 10.2210/pdb5z9c/pdb |
| NMR Information | BMRB: 36163 |
| Descriptor | Bromodomain-containing protein 4, 8-methoxy-6-methylquinolin-4(1H)-one (2 entities in total) |
| Functional Keywords | brd4, bromodomain, inhibitor, hiv, bet, mmqo, signaling protein |
| Biological source | Homo sapiens (Human) |
| Cellular location | Nucleus: O60885 |
| Total number of polymer chains | 1 |
| Total formula weight | 14136.35 |
| Authors | Zeng, L.,Zhou, M.-M. (deposition date: 2018-02-02, release date: 2018-02-14, Last modification date: 2024-05-15) |
| Primary citation | Abner, E.,Stoszko, M.,Zeng, L.,Chen, H.C.,Izquierdo-Bouldstridge, A.,Konuma, T.,Zorita, E.,Fanunza, E.,Zhang, Q.,Mahmoudi, T.,Zhou, M.M.,Filion, G.J.,Jordan, A. A New Quinoline BRD4 Inhibitor Targets a Distinct Latent HIV-1 Reservoir for Reactivation from Other "Shock" Drugs. J. Virol., 92:-, 2018 Cited by PubMed: 29343578DOI: 10.1128/JVI.02056-17 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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