5YEA

The crystal structure of Lp-PLA2 in complex with a novel inhibitor

Summary for 5YEA

• Entry DOI: 10.2210/pdb5yea/pdb
• Descriptor: Platelet-activating factor acetylhydrolase, SULFATE ION, 4-[[4-[4-chloranyl-3-(trifluoromethyl)phenoxy]-3-cyano-phenyl]sulfamoyl]benzoic acid, ... (4 entities in total)
• Functional Keywords: hydrolase inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 89093.51

Authors

Liu, Q.F.,Xu, Y.C. (deposition date: 2017-09-15, release date: 2018-07-25, Last modification date: 2023-11-22)

• Primary citation: Liu, Q.,Huang, F.,Yuan, X.,Wang, K.,Zou, Y.,Shen, J.,Xu, Y.; Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2.; J. Med. Chem., 60:10231-10244, 2017; PubMed: 29193967; DOI: 10.1021/acs.jmedchem.7b01530

Experimental method

X-RAY DIFFRACTION (1.805 Å)