5Y8W
Crystal Structure Analysis of the BRD4
Summary for 5Y8W
Entry DOI | 10.2210/pdb5y8w/pdb |
Descriptor | Bromodomain-containing protein 4, 5-bromanyl-2-methoxy-N-(3-methyl-6-oxidanyl-1,2-benzoxazol-5-yl)benzenesulfonamide, 1,2-ETHANEDIOL, ... (7 entities in total) |
Functional Keywords | brd4(1), bromodomain, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 17668.00 |
Authors | |
Primary citation | Zhang, M.,Zhang, Y.,Song, M.,Xue, X.,Wang, J.,Wang, C.,Zhang, C.,Li, C.,Xiang, Q.,Zou, L.,Wu, X.,Wu, C.,Dong, B.,Xue, W.,Zhou, Y.,Chen, H.,Wu, D.,Ding, K.,Xu, Y. Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC) J. Med. Chem., 61:3037-3058, 2018 Cited by PubMed: 29566488DOI: 10.1021/acs.jmedchem.8b00103 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
Download full validation report