5XXH
Crystal Structure Analysis of the CBP
Summary for 5XXH
Entry DOI | 10.2210/pdb5xxh/pdb |
Descriptor | CREB-binding protein, (3S)-1-[2-(3-ethanoylindol-1-yl)ethanoyl]piperidine-3-carboxylic acid, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | cbp, bromodomain, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 16306.03 |
Authors | |
Primary citation | Xiang, Q.,Wang, C.,Zhang, Y.,Xue, X.,Song, M.,Zhang, C.,Li, C.,Wu, C.,Li, K.,Hui, X.,Zhou, Y.,Smaill, J.B.,Patterson, A.V.,Wu, D.,Ding, K.,Xu, Y. Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer. Eur J Med Chem, 147:238-252, 2018 Cited by PubMed: 29448139DOI: 10.1016/j.ejmech.2018.01.087 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.62 Å) |
Structure validation
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