5WTC
Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor
Summary for 5WTC
Entry DOI | 10.2210/pdb5wtc/pdb |
Descriptor | Poly [ADP-ribose] polymerase 1, 1-[[4-fluoranyl-3-[4-[2,2,2-tris(fluoranyl)ethyl]piperazin-1-yl]carbonyl-phenyl]methyl]quinazoline-2,4-dione (2 entities in total) |
Functional Keywords | inhibitor, complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: P09874 |
Total number of polymer chains | 2 |
Total formula weight | 79805.12 |
Authors | Cao, R.,Wang, Y.L.,Zhou, J.,Huang, N.,Xu, B.L. (deposition date: 2016-12-11, release date: 2017-01-25) |
Primary citation | Cao, R.,Wang, Y.L.,Zhou, J.,Huang, N.,Xu, B.L. Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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