5WR7
Crystal structure of Trk-A complexed with a selective inhibitor CH7057288
Summary for 5WR7
Entry DOI | 10.2210/pdb5wr7/pdb |
Descriptor | High affinity nerve growth factor receptor, N-tert-butyl-2-[2-[6,6-dimethyl-8-(methylsulfonylamino)-11-oxidanylidene-naphtho[2,3-b][1]benzofuran-3-yl]ethynyl]-6-methyl-pyridine-4-carboxamide (3 entities in total) |
Functional Keywords | trk-a, kinase domain, high affinity nerve growth factor receptor, proteros biostructures gmbh, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 35315.63 |
Authors | Tanaka, H.,Blaesse, M.,Augustin, M.,Goesser, C. (deposition date: 2016-11-30, release date: 2017-12-06, Last modification date: 2018-12-19) |
Primary citation | Tanaka, H.,Sase, H.,Tsukaguchi, T.,Hasegawa, M.,Tanimura, H.,Yoshida, M.,Sakata, K.,Fujii, T.,Tachibana, Y.,Takanashi, K.,Higashida, A.,Hasegawa, K.,Ono, Y.,Oikawa, N.,Mio, T. Selective TRK Inhibitor CH7057288 against TRK Fusion-Driven Cancer. Mol. Cancer Ther., 17:2519-2529, 2018 Cited by PubMed: 30242093DOI: 10.1158/1535-7163.MCT-17-1180 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.76 Å) |
Structure validation
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