5WO4
JAK1 complexed with compound 28
Summary for 5WO4
Entry DOI | 10.2210/pdb5wo4/pdb |
Descriptor | Tyrosine-protein kinase JAK1, 3-[(4-chloro-3-methoxyphenyl)amino]-1-[(3R,4S)-4-cyanooxan-3-yl]-1H-pyrazole-4-carboxamide (3 entities in total) |
Functional Keywords | protein tyrosine kinase, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Endomembrane system; Peripheral membrane protein: P23458 |
Total number of polymer chains | 2 |
Total formula weight | 70244.81 |
Authors | Lesburg, C.A.,Patel, S.B. (deposition date: 2017-08-01, release date: 2017-12-06, Last modification date: 2024-03-06) |
Primary citation | Siu, T.,Brubaker, J.,Fuller, P.,Torres, L.,Zeng, H.,Close, J.,Mampreian, D.M.,Shi, F.,Liu, D.,Fradera, X.,Johnson, K.,Bays, N.,Kadic, E.,He, F.,Goldenblatt, P.,Shaffer, L.,Patel, S.B.,Lesburg, C.A.,Alpert, C.,Dorosh, L.,Deshmukh, S.V.,Yu, H.,Klappenbach, J.,Elwood, F.,Dinsmore, C.J.,Fernandez, R.,Moy, L.,Young, J.R. The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties. J. Med. Chem., 60:9676-9690, 2017 Cited by PubMed: 29156136DOI: 10.1021/acs.jmedchem.7b01135 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.84 Å) |
Structure validation
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