5WAE

ADC-7 in complex with boronic acid transition state inhibitor CR167

Summary for 5WAE

Entry DOI	10.2210/pdb5wae/pdb
Descriptor	Beta-lactamase, 3-(5,7,7-trihydroxy-2,2,7-trioxo-6-oxa-2lambda~6~-thia-3-aza-7lambda~5~-phospha-5-boraheptan-1-yl)benzoic acid (3 entities in total)
Functional Keywords	inhibitor, beta-lactamase, batsi, adc-7, antimicrobial protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Acinetobacter baumannii
Total number of polymer chains	4
Total formula weight	164646.19
Authors	Powers, R.A.,Wallar, B.J. (deposition date: 2017-06-26, release date: 2017-12-06, Last modification date: 2023-10-04)
Primary citation	Bouza, A.A.,Swanson, H.C.,Smolen, K.A.,VanDine, A.L.,Taracila, M.A.,Romagnoli, C.,Caselli, E.,Prati, F.,Bonomo, R.A.,Powers, R.A.,Wallar, B.J. Structure-Based Analysis of Boronic Acids as Inhibitors of Acinetobacter-Derived Cephalosporinase-7, a Unique Class C beta-Lactamase. ACS Infect Dis, 4:325-336, 2018 Cited by PubMed: 29144724 DOI: 10.1021/acsinfecdis.7b00152 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.804 Å)

Structure validation