5W8V
HUMAN HGPRT in complex with [(2-[(guanin-9-yl)methyl]propane-1,3-diyl)bis(oxy)]bis(methylene)diphosphonic acid
Summary for 5W8V
Entry DOI | 10.2210/pdb5w8v/pdb |
Descriptor | Hypoxanthine-guanine phosphoribosyltransferase, {[(2R)-2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-3-(2-phosphonoethoxy)propoxy]methyl}phosphonic acid, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | 6-oxopurine; phosphoribosyltransferase; hypoxanthine; guanine; nucleoside phosphonate, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P00492 |
Total number of polymer chains | 4 |
Total formula weight | 98753.98 |
Authors | Guddat, L.W.,Keough, D.T. (deposition date: 2017-06-22, release date: 2017-08-30, Last modification date: 2024-03-13) |
Primary citation | Spacek, P.,Keough, D.T.,Chavchich, M.,Dracinsky, M.,Janeba, Z.,Naesens, L.,Edstein, M.D.,Guddat, L.W.,Hockova, D. Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase. J. Med. Chem., 60:7539-7554, 2017 Cited by PubMed: 28813147DOI: 10.1021/acs.jmedchem.7b00926 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.346 Å) |
Structure validation
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