5UNY
Structure of rat neuronal nitric oxide synthase heme domain in complex with (RS)-3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-(2-(methylamino)propyl)benzonitrile
Summary for 5UNY
Entry DOI | 10.2210/pdb5uny/pdb |
Related | 5UNR 5UNS 5UNT 5UNU 5UNV 5UNW 5UNX 5UNZ 5UO0 5UO1 5UO2 5UO3 5UO4 5UO5 5UO6 5UO7 5UO8 5UO9 5UOA 5UOB 5UOC 5UOD |
Descriptor | Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (8 entities in total) |
Functional Keywords | nitric, oxide, synthase, inhibitor, complex, heme, enzyme, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Rattus norvegicus (Rat) |
Total number of polymer chains | 2 |
Total formula weight | 100965.83 |
Authors | Li, H.,Poulos, T.L. (deposition date: 2017-01-31, release date: 2017-05-03, Last modification date: 2024-03-06) |
Primary citation | Cinelli, M.A.,Li, H.,Chreifi, G.,Poulos, T.L.,Silverman, R.B. Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors. J. Med. Chem., 60:3958-3978, 2017 Cited by PubMed: 28422508DOI: 10.1021/acs.jmedchem.7b00259 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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