5TT7
Discovery of TAK-659, an Orally Available Investigational Inhibitor of Spleen Tyrosine Kinase (SYK)
Summary for 5TT7
Entry DOI | 10.2210/pdb5tt7/pdb |
Related | 5TR6 |
Descriptor | Tyrosine-protein kinase SYK, 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-5-one (3 entities in total) |
Functional Keywords | inhibitor, kinase, leukemia, lymphoma, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane : P43405 |
Total number of polymer chains | 1 |
Total formula weight | 34050.27 |
Authors | Yano, J.,Jennings, A.,Lam, B.,Hoffman, I.D. (deposition date: 2016-11-01, release date: 2016-11-30, Last modification date: 2024-03-06) |
Primary citation | Lam, B.,Arikawa, Y.,Cramlett, J.,Dong, Q.,de Jong, R.,Feher, V.,Grimshaw, C.E.,Farrell, P.J.,Hoffman, I.D.,Jennings, A.,Jones, B.,Matuszkiewicz, J.,Miura, J.,Miyake, H.,Natala, S.R.,Shi, L.,Takahashi, M.,Taylor, E.,Wyrick, C.,Yano, J.,Zalevsky, J.,Nie, Z. Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK). Bioorg. Med. Chem. Lett., 26:5947-5950, 2016 Cited by PubMed: 27839918DOI: 10.1016/j.bmcl.2016.10.087 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.77 Å) |
Structure validation
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