5TM9
Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the OBHS-ASC Analog, (E)-3-(4-((1R,4S,6R)-6-((3-chlorophenoxy)sulfonyl)-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl)phenyl)acrylic acid
Summary for 5TM9
Entry DOI | 10.2210/pdb5tm9/pdb |
Related | 5KRI 5KRJ 5KRK 5KRL 5KRM 5KRO 5TLD 5TLF 5TLG 5TLL 5TLM 5TLO 5TLP 5TLT 5TLU 5TLV 5TLX 5TLY 5TM1 5TM2 5TM3 5TM4 5TM5 5TM6 5TM7 5TM8 5TML 5TMM 5TMO 5TMQ 5TMR 5TMS 5TMT 5TMU 5TMV 5TMW 5TMZ 5TN1 5TN3 5TN4 5TN5 5TN6 5TN7 5TN8 |
Descriptor | Estrogen receptor, Nuclear receptor coactivator 2, 3-{4-[(1S,4S,6R)-6-[(3-chlorophenoxy)sulfonyl]-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl]phenyl}prop-2-enoic acid, ... (4 entities in total) |
Functional Keywords | nuclear receptor, transcription factor, ligand binding, protein-ligand complex, transcription |
Biological source | Homo sapiens (Human) More |
Cellular location | Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372 Nucleus: Q15596 |
Total number of polymer chains | 4 |
Total formula weight | 64383.65 |
Authors | Nwachukwu, J.C.,Srinivasan, S.,Bruno, N.E.,Nowak, J.,Kojetin, D.J.,Elemento, O.,Katzenellenbogen, J.A.,Nettles, K.W. (deposition date: 2016-10-12, release date: 2017-01-18, Last modification date: 2024-03-06) |
Primary citation | Nwachukwu, J.C.,Srinivasan, S.,Bruno, N.E.,Nowak, J.,Wright, N.J.,Minutolo, F.,Rangarajan, E.S.,Izard, T.,Yao, X.Q.,Grant, B.J.,Kojetin, D.J.,Elemento, O.,Katzenellenbogen, J.A.,Nettles, K.W. Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24:35-45, 2017 Cited by PubMed: 28042045DOI: 10.1016/j.chembiol.2016.11.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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