5T29

Crystal structure of 10E8 Fab light chain mutant3, against the MPER region of the HIV-1 Env, in complex with the MPER epitope scaffold T117v2

Summary for 5T29

• Entry DOI: 10.2210/pdb5t29/pdb
• Descriptor: Antibody 10E8 FAB HEAVY CHAIN, Antibody 10E8 FAB LIGHT CHAIN, 10E8 EPITOPE SCAFFOLD T117V2, ... (6 entities in total)
• Functional Keywords: hiv-1 gp41 mper, 10e8 fab, lipid membrane, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 67225.69

Authors

Irimia, A.,Wilson, I.A. (deposition date: 2016-08-23, release date: 2017-03-08, Last modification date: 2023-10-04)

• Primary citation: Irimia, A.,Serra, A.M.,Sarkar, A.,Jacak, R.,Kalyuzhniy, O.,Sok, D.,Saye-Francisco, K.L.,Schiffner, T.,Tingle, R.,Kubitz, M.,Adachi, Y.,Stanfield, R.L.,Deller, M.C.,Burton, D.R.,Schief, W.R.,Wilson, I.A.; Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design.; PLoS Pathog., 13:e1006212-e1006212, 2017; PubMed: 28225819; DOI: 10.1371/journal.ppat.1006212

Experimental method

X-RAY DIFFRACTION (2.03 Å)