5SD6
Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-892
Summary for 5SD6
Entry DOI | 10.2210/pdb5sd6/pdb |
Group deposition | DHFR structures, SSGCID (G_1002223) |
Descriptor | Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-ethyl-5-(4-{2-[2-(1H-tetrazol-5-yl)ethyl]phenoxy}butoxy)pyrimidine-2,4-diamine, ... (7 entities in total) |
Functional Keywords | homo sapiens, dhfr, nadp, folate, oxidoreductase-oxidoreductase inhibitor complex, structural genomics, seattle structural genomics center for infectious disease, ssgcid, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 23141.27 |
Authors | Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2021-12-20, release date: 2022-02-09, Last modification date: 2024-05-22) |
Primary citation | Mayclin, S.J.,Fairman, J.W.,Dranow, D.M.,Conrady, D.G.,Fox III, D.,Lukacs, C.M.,Lorimer, D.D.,Horanyi, P.S.,Edwards, T.E.,Abendroth, J. Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-892 to be published, |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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