5SCV

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-889

Summary for 5SCV

• Entry DOI: 10.2210/pdb5scv/pdb
• Group deposition: DHFR structures, SSGCID (G_1002223)
• Descriptor: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-ethyl-5-(4-{3-[3-(1H-tetrazol-5-yl)propyl]phenoxy}butoxy)pyrimidine-2,4-diamine, ... (5 entities in total)
• Functional Keywords: mycobacterium tuberculosis, dhfr, nadp, folate, oxidoreductase-oxidoreductase inhibitor complex, structural genomics, seattle structural genomics center for infectious disease, ssgcid, oxidoreductase/oxidoreductase inhibitor
• Biological source: Mycobacterium tuberculosis H37Rv
• Total number of polymer chains: 2
• Total formula weight: 42047.42

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2021-12-20, release date: 2022-02-09, Last modification date: 2024-05-22)

• Primary citation: Mayclin, S.J.,Fairman, J.W.,Dranow, D.M.,Conrady, D.G.,Fox III, D.,Lukacs, C.M.,Lorimer, D.D.,Horanyi, P.S.,Edwards, T.E.,Abendroth, J.; Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-889; to be published,

Experimental method

X-RAY DIFFRACTION (1.55 Å)