5SAW
DDR1, 2-[3-(2-pyridin-3-ylethynyl)phenyl]-N-[3-(trifluoromethyl)phenyl]acetamide, 1.601A, P212121, Rfree=22.6%
Summary for 5SAW
Entry DOI | 10.2210/pdb5saw/pdb |
Group deposition | Novel Potent and Highly Selective DDR1 Inhibitors from Structure-guided Drug Design (G_1002213) |
Descriptor | Epithelial discoidin domain-containing receptor 1, 2-{3-[(pyridin-3-yl)ethynyl]phenyl}-N-[3-(trifluoromethyl)phenyl]acetamide, IODIDE ION, ... (4 entities in total) |
Functional Keywords | rtk, receptor tyrosine kinase, collagen, discoidin domain;, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 38152.26 |
Authors | Stihle, M.,Richter, H.,Benz, J.,Hochstrasser, R.,Rudolph, M.G. (deposition date: 2021-06-22, release date: 2022-06-29, Last modification date: 2024-04-03) |
Primary citation | Richter, H.,Prunotto, M.,Kuhn, B.,Rudolph, M.G. Crystal Structure of a DDR1 complex To be published, |
Experimental method | X-RAY DIFFRACTION (1.601 Å) |
Structure validation
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