5QJ2
CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) OMPLEX WITH COMPOUND-20 AKA 7-((3-(1-METHYL-1H-PYRAZOL-3- YL)BENZYL)OXY)- 1H-[1,2,3]TRIAZOLO[4,5-B]PYRIDIN-5-AMINE
Summary for 5QJ2
Entry DOI | 10.2210/pdb5qj2/pdb |
Group deposition | MPO (G_1002056) |
Descriptor | Myeloperoxidase, CHLORIDE ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total) |
Functional Keywords | myeloperoxidase, metal binding protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 272400.99 |
Authors | Khan, J.A. (deposition date: 2018-09-26, release date: 2019-02-06, Last modification date: 2024-10-09) |
Primary citation | Wurtz, N.R.,Viet, A.,Shaw, S.A.,Dilger, A.,Valente, M.N.,Khan, J.A.,Jusuf, S.,Narayanan, R.,Fernando, G.,Lo, F.,Liu, X.,Locke, G.A.,Kopcho, L.,Abell, L.M.,Sleph, P.,Basso, M.,Zhao, L.,Wexler, R.R.,Duclos, F.,Kick, E.K. Potent Triazolopyridine Myeloperoxidase Inhibitors. ACS Med Chem Lett, 9:1175-1180, 2018 Cited by PubMed: 30613322DOI: 10.1021/acsmedchemlett.8b00308 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.82 Å) |
Structure validation
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