5Q03

Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[5-(2-methylpropyl)thiophen-2-yl]sulfonylurea

Summary for 5Q03

• Entry DOI: 10.2210/pdb5q03/pdb
• Group deposition: Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with allosteric inhibitors (G_1002030)
• Descriptor: Fructose-1,6-bisphosphatase 1, N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(2-methylpropyl)thiophene-2-sulfonamide (3 entities in total)
• Functional Keywords: d3r docking, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 8
• Total formula weight: 298270.20

Authors

Ruf, A.,Joseph, C.,Alker, A.,Banner, D.,Tetaz, T.,Benz, J.,Kuhn, B.,Rudolph, M.G.,Yang, H.,Shao, C.,Burley, S.K. (deposition date: 2017-04-18, release date: 2019-01-09, Last modification date: 2024-03-06)

• Primary citation: Ruf, A.,Joseph, C.,Alker, A.,Banner, D.,Tetaz, T.,Benz, J.,Kuhn, B.,Rudolph, M.G.; Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[5-(2-methylpropyl)thiophen-2-yl]sulfonylurea; To be published,

Experimental method

X-RAY DIFFRACTION (2.31 Å)