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5NQE

Human PARP14 (ARTD8), catalytic fragment in complex with an N-aryl piperazine inhibitor

Summary for 5NQE
Entry DOI10.2210/pdb5nqe/pdb
DescriptorPoly [ADP-ribose] polymerase 14, 3-[[4-[4-(4-fluorophenyl)piperazin-1-yl]-4-oxidanylidene-butanoyl]amino]benzamide (3 entities in total)
Functional Keywordsadp-ribosylation, inhibitor complex, transferase domain, transferase
Biological sourceHomo sapiens (Human)
Cellular locationNucleus: Q460N5
Total number of polymer chains2
Total formula weight45034.04
Authors
Karlberg, T.,Thorsell, A.G.,Schuler, H. (deposition date: 2017-04-20, release date: 2017-05-24, Last modification date: 2024-01-17)
Primary citationUpton, K.,Meyers, M.,Thorsell, A.G.,Karlberg, T.,Holechek, J.,Lease, R.,Schey, G.,Wolf, E.,Lucente, A.,Schuler, H.,Ferraris, D.
Design and synthesis of potent inhibitors of the mono(ADP-ribosyl)transferase, PARP14.
Bioorg. Med. Chem. Lett., 27:2907-2911, 2017
Cited by
PubMed: 28495083
DOI: 10.1016/j.bmcl.2017.04.089
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.71 Å)
Structure validation

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