5NQE
Human PARP14 (ARTD8), catalytic fragment in complex with an N-aryl piperazine inhibitor
Summary for 5NQE
Entry DOI | 10.2210/pdb5nqe/pdb |
Descriptor | Poly [ADP-ribose] polymerase 14, 3-[[4-[4-(4-fluorophenyl)piperazin-1-yl]-4-oxidanylidene-butanoyl]amino]benzamide (3 entities in total) |
Functional Keywords | adp-ribosylation, inhibitor complex, transferase domain, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: Q460N5 |
Total number of polymer chains | 2 |
Total formula weight | 45034.04 |
Authors | Karlberg, T.,Thorsell, A.G.,Schuler, H. (deposition date: 2017-04-20, release date: 2017-05-24, Last modification date: 2024-01-17) |
Primary citation | Upton, K.,Meyers, M.,Thorsell, A.G.,Karlberg, T.,Holechek, J.,Lease, R.,Schey, G.,Wolf, E.,Lucente, A.,Schuler, H.,Ferraris, D. Design and synthesis of potent inhibitors of the mono(ADP-ribosyl)transferase, PARP14. Bioorg. Med. Chem. Lett., 27:2907-2911, 2017 Cited by PubMed: 28495083DOI: 10.1016/j.bmcl.2017.04.089 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.71 Å) |
Structure validation
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