5NK5
Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 1m
Summary for 5NK5
Entry DOI | 10.2210/pdb5nk5/pdb |
Descriptor | Ephrin type-A receptor 2, 2-[[3-[(3-aminophenyl)carbamoyl]phenyl]amino]-~{N}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide (3 entities in total) |
Functional Keywords | inhibitor, complex, protein tyrosine kinase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 34940.81 |
Authors | Kudlinzki, D.,Linhard, V.L.,Witt, K.,Gande, S.L.,Saxena, K.,Heinzlmeir, S.,Medard, G.,Kuester, B.,Schwalbe, H. (deposition date: 2017-03-31, release date: 2017-06-07, Last modification date: 2024-01-17) |
Primary citation | Heinzlmeir, S.,Lohse, J.,Treiber, T.,Kudlinzki, D.,Linhard, V.,Gande, S.L.,Sreeramulu, S.,Saxena, K.,Liu, X.,Wilhelm, M.,Schwalbe, H.,Kuster, B.,Medard, G. Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors. ChemMedChem, 12:999-1011, 2017 Cited by PubMed: 28544567DOI: 10.1002/cmdc.201700217 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.329 Å) |
Structure validation
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