5NK4
Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 2c
Summary for 5NK4
Entry DOI | 10.2210/pdb5nk4/pdb |
Descriptor | Ephrin type-A receptor 2, 2-[[3-[[(4~{R})-3,3-bis(fluoranyl)piperidin-4-yl]carbamoyl]phenyl]amino]-~{N}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, protein tyrosine kinase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 35030.88 |
Authors | Kudlinzki, D.,Linhard, V.L.,Witt, K.,Gande, S.L.,Saxena, K.,Heinzlmeir, S.,Medard, G.,Kuester, B.,Schwalbe, H. (deposition date: 2017-03-31, release date: 2017-06-07, Last modification date: 2024-01-17) |
Primary citation | Heinzlmeir, S.,Lohse, J.,Treiber, T.,Kudlinzki, D.,Linhard, V.,Gande, S.L.,Sreeramulu, S.,Saxena, K.,Liu, X.,Wilhelm, M.,Schwalbe, H.,Kuster, B.,Medard, G. Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors. ChemMedChem, 12:999-1011, 2017 Cited by PubMed: 28544567DOI: 10.1002/cmdc.201700217 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
Download full validation report