5NDZ
Crystal structure of a thermostabilised human protease-activated receptor-2 (PAR2) in complex with AZ3451 at 3.6 angstrom resolution
Summary for 5NDZ
Entry DOI | 10.2210/pdb5ndz/pdb |
Descriptor | Lysozyme,Proteinase-activated receptor 2,Soluble cytochrome b562,Proteinase-activated receptor 2, 2-(6-bromanyl-1,3-benzodioxol-5-yl)-~{N}-(4-cyanophenyl)-1-[(1~{S})-1-cyclohexylethyl]benzimidazole-5-carboxamide, SODIUM ION, ... (4 entities in total) |
Functional Keywords | membrane protein, gpcr, 7tm |
Biological source | Enterobacteria phage T4 More |
Cellular location | Cell membrane; Multi-pass membrane protein: P55085 |
Total number of polymer chains | 1 |
Total formula weight | 70153.35 |
Authors | Cheng, R.K.Y.,Fiez-Vandal, C.,Schlenker, O.,Edman, K.,Aggeler, B.,Brown, D.G.,Brown, G.,Cooke, R.M.,Dumelin, C.E.,Dore, A.S.,Geschwindner, S.,Grebner, C.,Hermansson, N.-O.,Jazayeri, A.,Johansson, P.,Leong, L.,Prihandoko, R.,Rappas, M.,Soutter, H.,Snijder, A.,Sundstrom, L.,Tehan, B.,Thornton, P.,Troast, D.,Wiggin, G.,Zhukov, A.,Marshall, F.H.,Dekker, N. (deposition date: 2017-03-09, release date: 2017-05-03, Last modification date: 2024-01-17) |
Primary citation | Cheng, R.K.Y.,Fiez-Vandal, C.,Schlenker, O.,Edman, K.,Aggeler, B.,Brown, D.G.,Brown, G.A.,Cooke, R.M.,Dumelin, C.E.,Dore, A.S.,Geschwindner, S.,Grebner, C.,Hermansson, N.O.,Jazayeri, A.,Johansson, P.,Leong, L.,Prihandoko, R.,Rappas, M.,Soutter, H.,Snijder, A.,Sundstrom, L.,Tehan, B.,Thornton, P.,Troast, D.,Wiggin, G.,Zhukov, A.,Marshall, F.H.,Dekker, N. Structural insight into allosteric modulation of protease-activated receptor 2. Nature, 545:112-115, 2017 Cited by PubMed: 28445455DOI: 10.1038/nature22309 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.6 Å) |
Structure validation
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