5ML4
The crystal structure of PDE6D in complex to inhibitor-7
Summary for 5ML4
Entry DOI | 10.2210/pdb5ml4/pdb |
Descriptor | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, 4-[[[4-[(4-chlorophenyl)methyl-cyclopentyl-sulfamoyl]phenyl]sulfonyl-(piperidin-4-ylmethyl)amino]methyl]-2-(methylamino)benzoic acid (3 entities in total) |
Functional Keywords | prenyl binding protein, farnesylated kras, plasmam membrane, arl2, lipid binding protein |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytosol : O43924 |
Total number of polymer chains | 1 |
Total formula weight | 17999.08 |
Authors | Fansa, E.K.,Martin-Gago, P.,waldmann, H.,Wittinghofer, A. (deposition date: 2016-12-06, release date: 2017-02-01, Last modification date: 2024-01-17) |
Primary citation | Martin-Gago, P.,Fansa, E.K.,Klein, C.H.,Murarka, S.,Janning, P.,Schurmann, M.,Metz, M.,Ismail, S.,Schultz-Fademrecht, C.,Baumann, M.,Bastiaens, P.I.,Wittinghofer, A.,Waldmann, H. A PDE6 delta-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2. Angew. Chem. Int. Ed. Engl., 56:2423-2428, 2017 Cited by PubMed: 28106325DOI: 10.1002/anie.201610957 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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