5MAJ
CATHEPSIN L IN COMPLEX WITH 4-[cyclopentyl(imidazo[1,2-a]pyridin-2-ylmethyl)amino]-6-morpholino-1,3,5-triazine-2-carbonitrile
Summary for 5MAJ
Entry DOI | 10.2210/pdb5maj/pdb |
Related | 5MAE |
Descriptor | Cathepsin L1, ~{N}-cyclopentyl-~{N}-(imidazo[1,2-a]pyridin-2-ylmethyl)-4-(iminomethyl)-6-morpholin-4-yl-1,3,5-triazin-2-amine, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Lysosome: P07711 |
Total number of polymer chains | 1 |
Total formula weight | 24660.25 |
Authors | Kuglstatter, A.,Stihle, M.,Benz, J. (deposition date: 2016-11-03, release date: 2017-01-11, Last modification date: 2017-02-22) |
Primary citation | Giroud, M.,Ivkovic, J.,Martignoni, M.,Fleuti, M.,Trapp, N.,Haap, W.,Kuglstatter, A.,Benz, J.,Kuhn, B.,Schirmeister, T.,Diederich, F. Inhibition of the Cysteine Protease Human Cathepsin L by Triazine Nitriles: AmideHeteroarene pi-Stacking Interactions and Chalcogen Bonding in the S3 Pocket. ChemMedChem, 12:257-270, 2017 Cited by PubMed: 27992115DOI: 10.1002/cmdc.201600563 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1 Å) |
Structure validation
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