5M2I
Structure of human Tumor Necrosis Factor (TNF) in complex with the Llama VHH1
Summary for 5M2I
Entry DOI | 10.2210/pdb5m2i/pdb |
Descriptor | Tumor necrosis factor, VHH1 (3 entities in total) |
Functional Keywords | human tumor necrosis factor (tnf) llama vhh1, cytokine |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane ; Single-pass type II membrane protein . Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted. C-domain 1: Secreted. C-domain 2: Secreted: P01375 |
Total number of polymer chains | 12 |
Total formula weight | 184719.64 |
Authors | Cambillau, C.,Spinelli, S.,Desmyter, A.,de Haard, H. (deposition date: 2016-10-13, release date: 2017-08-30, Last modification date: 2024-01-17) |
Primary citation | Beirnaert, E.,Desmyter, A.,Spinelli, S.,Lauwereys, M.,Aarden, L.,Dreier, T.,Loris, R.,Silence, K.,Pollet, C.,Cambillau, C.,de Haard, H. Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions. Front Immunol, 8:867-867, 2017 Cited by PubMed: 28824615DOI: 10.3389/fimmu.2017.00867 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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