5LYY
Fragment-based inhibitors of Lipoprotein associated Phospholipase A2
Summary for 5LYY
Entry DOI | 10.2210/pdb5lyy/pdb |
Descriptor | Platelet-activating factor acetylhydrolase, 3-[2-(4-fluoranylphenoxy)ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione (3 entities in total) |
Functional Keywords | lp-pla2 phospholipase, hydrolase, lipid metabolism, inhibitors, lp-pla2#4 |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted, extracellular space: Q13093 |
Total number of polymer chains | 1 |
Total formula weight | 44509.46 |
Authors | Woolford, A.,Day, P. (deposition date: 2016-09-29, release date: 2016-12-21, Last modification date: 2024-05-08) |
Primary citation | Woolford, A.J.,Day, P.J.,Beneton, V.,Berdini, V.,Coyle, J.E.,Dudit, Y.,Grondin, P.,Huet, P.,Lee, L.Y.,Manas, E.S.,McMenamin, R.L.,Murray, C.W.,Page, L.W.,Patel, V.K.,Potvain, F.,Rich, S.J.,Sang, Y.,Somers, D.O.,Trottet, L.,Wan, Z.,Zhang, X. Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2). J. Med. Chem., 59:10738-10749, 2016 Cited by PubMed: 27933945DOI: 10.1021/acs.jmedchem.6b01427 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.17 Å) |
Structure validation
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