5LL9
Crystal structure of human carbonic anhydrase isozyme XII with 4-(1H-benzimidazol-1-ylacetyl)-2-chlorobenzenesulfonamide
Summary for 5LL9
Entry DOI | 10.2210/pdb5ll9/pdb |
Descriptor | Carbonic anhydrase 12, ZINC ION, 4-[2-(benzimidazol-1-yl)ethanoyl]-2-chloranyl-benzenesulfonamide, ... (6 entities in total) |
Functional Keywords | drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor comple, lyase |
Biological source | Homo sapiens (Human) |
Cellular location | Membrane; Single-pass type I membrane protein: O43570 |
Total number of polymer chains | 4 |
Total formula weight | 122301.01 |
Authors | Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2016-07-27, release date: 2017-08-16, Last modification date: 2024-01-10) |
Primary citation | Capkauskaite, E.,Linkuviene, V.,Smirnov, A.,Milinaviciute, G.,Timm, D.,Kasiliauskaite, A.,Manakova, E.,Grazulis, S.,Matulis, D. Combinatorial Design of Isoform-Selective N-Alkylated Benzimidazole-Based Inhibitors of Carbonic Anhydrases Chemistryselect, 2017 Cited by DOI: 10.1002/slct.201700531PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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