5LL4
Crystal structure of human carbonic anhydrase isozyme II with 4-(1H-benzimidazol-1-ylacetyl)benzenesulfonamide
Summary for 5LL4
| Entry DOI | 10.2210/pdb5ll4/pdb |
| Descriptor | Carbonic anhydrase 2, ZINC ION, DIMETHYL SULFOXIDE, ... (8 entities in total) |
| Functional Keywords | drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm : P00918 |
| Total number of polymer chains | 2 |
| Total formula weight | 60136.49 |
| Authors | Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2016-07-26, release date: 2017-08-16, Last modification date: 2024-01-10) |
| Primary citation | Capkauskaite, E.,Linkuviene, V.,Smirnov, A.,Milinaviciute, G.,Timm, D.,Kasiliauskaite, A.,Manakova, E.,Grazulis, S.,Matulis, D. Combinatorial Design of Isoform-Selective N-Alkylated Benzimidazole-Based Inhibitors of Carbonic Anhydrases Chemistryselect, 2017 Cited by DOI: 10.1002/slct.201700531PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.12 Å) |
Structure validation
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