5LJQ
Crystal structure of human carbonic anhydrase II in complex with the 4-(4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl)benzenesulfonamide inhibitor
Summary for 5LJQ
Entry DOI | 10.2210/pdb5ljq/pdb |
Descriptor | Carbonic anhydrase 2, ZINC ION, 1-[4-[azanyl-bis(oxidanyl)-$l^{4}-sulfanyl]phenyl]-4-(phenoxymethyl)-1,2,3-triazole, ... (5 entities in total) |
Functional Keywords | lyase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29560.67 |
Authors | Ferraroni, M.,Supuran, C. (deposition date: 2016-07-19, release date: 2017-06-21, Last modification date: 2024-01-10) |
Primary citation | Nocentini, A.,Ferraroni, M.,Carta, F.,Ceruso, M.,Gratteri, P.,Lanzi, C.,Masini, E.,Supuran, C.T. Benzenesulfonamides Incorporating Flexible Triazole Moieties Are Highly Effective Carbonic Anhydrase Inhibitors: Synthesis and Kinetic, Crystallographic, Computational, and Intraocular Pressure Lowering Investigations. J. Med. Chem., 59:10692-10704, 2016 Cited by PubMed: 27933963DOI: 10.1021/acs.jmedchem.6b01389 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.05 Å) |
Structure validation
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