5KZ7
Mark2 complex with 7-[(1S)-1-(4-fluorophenyl)ethyl]-5,5-dimethyl-2-(3-pyridylamino)pyrrolo[2,3-d]pyrimidin-6-one
Summary for 5KZ7
Entry DOI | 10.2210/pdb5kz7/pdb |
Related | 5KZ8 |
Descriptor | Serine/threonine-protein kinase MARK2, 7-[(1~{S})-1-(4-fluorophenyl)ethyl]-5,5-dimethyl-2-(pyridin-3-ylamino)pyrrolo[2,3-d]pyrimidin-6-one (2 entities in total) |
Functional Keywords | mark, serine/threonine-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane; Peripheral membrane protein: Q7KZI7 |
Total number of polymer chains | 2 |
Total formula weight | 80867.01 |
Authors | Su, H.P.,Munshi, S.K. (deposition date: 2016-07-23, release date: 2017-05-31, Last modification date: 2023-10-04) |
Primary citation | Katz, J.D.,Haidle, A.,Childers, K.K.,Zabierek, A.A.,Jewell, J.P.,Hou, Y.,Altman, M.D.,Szewczak, A.,Chen, D.,Harsch, A.,Hayashi, M.,Warren, L.,Hutton, M.,Nuthall, H.,Su, H.P.,Munshi, S.,Stanton, M.G.,Davies, I.W.,Munoz, B.,Northrup, A. Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors. Bioorg. Med. Chem. Lett., 27:114-120, 2017 Cited by PubMed: 27816515DOI: 10.1016/j.bmcl.2016.08.068 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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