5KQ5
AMPK bound to allosteric activator
Summary for 5KQ5
Entry DOI | 10.2210/pdb5kq5/pdb |
Descriptor | 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (9 entities in total) |
Functional Keywords | kinase allosteric activator, transferase |
Biological source | Rattus norvegicus (Rat) More |
Cellular location | Cytoplasm : P54645 |
Total number of polymer chains | 3 |
Total formula weight | 120426.34 |
Authors | Calabrese, M.F.,Kurumbail, R.G. (deposition date: 2016-07-05, release date: 2016-08-17, Last modification date: 2023-10-04) |
Primary citation | Cameron, K.O.,Kung, D.W.,Kalgutkar, A.S.,Kurumbail, R.G.,Miller, R.,Salatto, C.T.,Ward, J.,Withka, J.M.,Bhattacharya, S.K.,Boehm, M.,Borzilleri, K.A.,Brown, J.A.,Calabrese, M.,Caspers, N.L.,Cokorinos, E.,Conn, E.L.,Dowling, M.S.,Edmonds, D.J.,Eng, H.,Fernando, D.P.,Frisbie, R.,Hepworth, D.,Landro, J.,Mao, Y.,Rajamohan, F.,Reyes, A.R.,Rose, C.R.,Ryder, T.,Shavnya, A.,Smith, A.C.,Tu, M.,Wolford, A.C.,Xiao, J. Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy. J.Med.Chem., 59:8068-8081, 2016 Cited by PubMed: 27490827DOI: 10.1021/acs.jmedchem.6b00866 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.41 Å) |
Structure validation
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