5KIR
The Structure of Vioxx Bound to Human COX-2
Summary for 5KIR
| Entry DOI | 10.2210/pdb5kir/pdb |
| Descriptor | Prostaglandin G/H synthase 2, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Rofecoxib, ... (9 entities in total) |
| Functional Keywords | cyclooxyrgenase, vioxx, rofecoxib, cox, oxidoreductase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 131003.98 |
| Authors | Orlando, B.J.,Malkowski, M.G. (deposition date: 2016-06-16, release date: 2016-09-28, Last modification date: 2023-09-27) |
| Primary citation | Orlando, B.J.,Malkowski, M.G. Crystal structure of rofecoxib bound to human cyclooxygenase-2. Acta Crystallogr.,Sect.F, 72:772-776, 2016 Cited by PubMed: 27710942DOI: 10.1107/S2053230X16014230 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.697 Å) |
Structure validation
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