5KAE
Crystal structure of human PI3K-gamma in complex with quinoline-containing inhibitor 5g
Summary for 5KAE
Entry DOI | 10.2210/pdb5kae/pdb |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, 4-azanyl-6-[[(1~{S})-1-(6-fluoranyl-3-phenyl-4-piperazin-1-ylcarbonyl-quinolin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile, ... (4 entities in total) |
Functional Keywords | phosphotransferase, inhibitor, inflammatory disease, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P48736 |
Total number of polymer chains | 1 |
Total formula weight | 110551.73 |
Authors | Whittington, D.A.,Tang, J.,Yakowec, P. (deposition date: 2016-06-01, release date: 2017-06-21, Last modification date: 2023-09-27) |
Primary citation | Gonzalez-Lopez de Turiso, F.,Hao, X.,Shin, Y.,Bui, M.,Campuzano, I.,Cardozo, M.,Dunn, M.C.,Duquette, J.,Fisher, B.,Foti, R.S.,Henne, K.,He, X.,Hu, Y.-L.,Kelly, R.C.,Johnson, M.G.,Lucas, B.S.,McCarter, J.,McGee, L.R.,Medina, J.C.,Metz, D.,San Miguel, T.,Mohn, D.,Tran, T.,Vissinga, C.,Wannberg, S.,Whittington, D.A.,Whoriskey, J.,Yu, G.,Zalameda, L.,Zhang, X.,Cushing, T.D. Discovery and in vivo evaluation of the potent and selective PI3K-delta inhibitors AM-0687 and AM-1430 To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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