5JZ7

NGF IN COMPLEX WITH MEDI578 scFv

Summary for 5JZ7

Entry DOI	10.2210/pdb5jz7/pdb
Descriptor	Beta-nerve growth factor, MEDI578 scFv, heavy chain, MEDI578 scFv, light chain (3 entities in total)
Functional Keywords	antibody, complex, epitope, ngf, signaling protein
Biological source	Homo sapiens (Human) More
Cellular location	Secreted: P01138
Total number of polymer chains	12
Total formula weight	156350.41
Authors	Olsson, L.-L.,Aagaard, A. (deposition date: 2016-05-16, release date: 2017-01-11, Last modification date: 2024-01-10)
Primary citation	Dobson, C.L.,Devine, P.W.,Phillips, J.J.,Higazi, D.R.,Lloyd, C.,Popovic, B.,Arnold, J.,Buchanan, A.,Lewis, A.,Goodman, J.,van der Walle, C.F.,Thornton, P.,Vinall, L.,Lowne, D.,Aagaard, A.,Olsson, L.L.,Ridderstad Wollberg, A.,Welsh, F.,Karamanos, T.K.,Pashley, C.L.,Iadanza, M.G.,Ranson, N.A.,Ashcroft, A.E.,Kippen, A.D.,Vaughan, T.J.,Radford, S.E.,Lowe, D.C. Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo. Sci Rep, 6:38644-38644, 2016 Cited by PubMed: 27995962 DOI: 10.1038/srep38644 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.4 Å)

Structure validation