5JVY

Crystal structure of S121P murine COX-2 mutant

Summary for 5JVY

• Entry DOI: 10.2210/pdb5jvy/pdb
• Related: 5JVZ 5JW1
• Descriptor: Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: cyclooxygenase, cox, nsaid, oxidoreductase
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 2
• Total formula weight: 130396.11

Authors

Orlando, B.J.,Malkowski, M.G.,Dong, L. (deposition date: 2016-05-11, release date: 2016-10-26, Last modification date: 2023-09-27)

• Primary citation: Dong, L.,Yuan, C.,Orlando, B.J.,Malkowski, M.G.,Smith, W.L.; Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit.; J.Biol.Chem., 291:25641-25655, 2016; PubMed: 27756840; DOI: 10.1074/jbc.M116.757310

Experimental method

X-RAY DIFFRACTION (2.36 Å)