5JV0
Crystal structure of human FPPS in complex with an allosteric inhibitor CL-08-038
Summary for 5JV0
Entry DOI | 10.2210/pdb5jv0/pdb |
Related | 5JUZ 5JV1 5JV2 |
Descriptor | Farnesyl pyrophosphate synthase, SULFATE ION, [(1R)-2-(3-fluorophenyl)-1-{[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}ethyl]phosphonic acid, ... (4 entities in total) |
Functional Keywords | transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P14324 |
Total number of polymer chains | 1 |
Total formula weight | 44667.40 |
Authors | Park, J.,Leung, C.Y.,Tsantrizos, Y.S.,Berghuis, A.M. (deposition date: 2016-05-10, release date: 2017-03-15, Last modification date: 2023-09-27) |
Primary citation | Park, J.,Leung, C.Y.,Matralis, A.N.,Lacbay, C.M.,Tsakos, M.,Fernandez De Troconiz, G.,Berghuis, A.M.,Tsantrizos, Y.S. Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase. J. Med. Chem., 60:2119-2134, 2017 Cited by PubMed: 28208018DOI: 10.1021/acs.jmedchem.6b01888 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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