5JOP
Crystal structure of anti-glycan antibody Fab14.22 in complex with Streptococcus pneumoniae serotype 14 tetrasaccharide at 1.75 A
Summary for 5JOP
Entry DOI | 10.2210/pdb5jop/pdb |
Related | 5JOR |
Descriptor | Fab 14.22 light chain, Fab14.22 heavy chain, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose-(1-6)-[beta-D-galactopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | s. pneumoniae serotype 14, anti-glycan b cells, synthetic conjugate vaccine, nanomolar affinity anti-glycan antibody, immune system, immune system-bacterial glycan complex |
Biological source | Mus musculus More |
Total number of polymer chains | 4 |
Total formula weight | 105887.20 |
Authors | Sarkar, A.,Irimia, A.,Teyton, L.,Wilson, I.A. (deposition date: 2016-05-02, release date: 2017-03-22, Last modification date: 2023-09-27) |
Primary citation | Polonskaya, Z.,Deng, S.,Sarkar, A.,Kain, L.,Comellas-Aragones, M.,McKay, C.S.,Kaczanowska, K.,Holt, M.,McBride, R.,Palomo, V.,Self, K.M.,Taylor, S.,Irimia, A.,Mehta, S.R.,Dan, J.M.,Brigger, M.,Crotty, S.,Schoenberger, S.P.,Paulson, J.C.,Wilson, I.A.,Savage, P.B.,Finn, M.G.,Teyton, L. T cells control the generation of nanomolar-affinity anti-glycan antibodies. J. Clin. Invest., 127:1491-1504, 2017 Cited by PubMed: 28287405DOI: 10.1172/JCI91192 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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