5JI6
Potent, Reversible MetAP2 Inhibitors via FBDD
Summary for 5JI6
Entry DOI | 10.2210/pdb5ji6/pdb |
Related | 5JFR 5JHU |
Descriptor | Methionine aminopeptidase 2, MANGANESE (II) ION, SULFATE ION, ... (5 entities in total) |
Functional Keywords | hydrolase, peptidase, metal ion binding, proteolysis, hydrolase4-hydrolase inhibitor complex, hydrolase4/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P50579 |
Total number of polymer chains | 1 |
Total formula weight | 41839.16 |
Authors | Dougan, D.R.,Lawson, J.D. (deposition date: 2016-04-21, release date: 2016-05-25, Last modification date: 2017-11-22) |
Primary citation | Cheruvallath, Z.,Tang, M.,McBride, C.,Komandla, M.,Miura, J.,Ton-Nu, T.,Erikson, P.,Feng, J.,Farrell, P.,Lawson, J.D.,Vanderpool, D.,Wu, Y.,Dougan, D.R.,Plonowski, A.,Holub, C.,Larson, C. Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design-Part 1. Bioorg.Med.Chem.Lett., 26:2774-2778, 2016 Cited by PubMed: 27155900DOI: 10.1016/j.bmcl.2016.04.073 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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