5J18
Solution structure of Ras Binding Domain (RBD) of B-Raf complexed with Rigosertib (Complex I)
Summary for 5J18
Entry DOI | 10.2210/pdb5j18/pdb |
Related | 5J17 5J2R |
NMR Information | BMRB: 30048 |
Descriptor | Serine/threonine-protein kinase B-raf, N-[2-methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine (2 entities in total) |
Functional Keywords | mapk, pi3k, protein binding |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P15056 |
Total number of polymer chains | 1 |
Total formula weight | 10762.57 |
Authors | Dutta, K.,Vasquez-Del Carpio, R.,Aggarwal, A.K.,Reddy, E.P. (deposition date: 2016-03-29, release date: 2016-05-04, Last modification date: 2024-05-01) |
Primary citation | Athuluri-Divakar, S.K.,Vasquez-Del Carpio, R.,Dutta, K.,Baker, S.J.,Cosenza, S.C.,Basu, I.,Gupta, Y.K.,Reddy, M.V.,Ueno, L.,Hart, J.R.,Vogt, P.K.,Mulholland, D.,Guha, C.,Aggarwal, A.K.,Reddy, E.P. A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling. Cell, 165:643-655, 2016 Cited by PubMed: 27104980DOI: 10.1016/j.cell.2016.03.045 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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