5IWD

HCMV DNA polymerase subunit UL44 complex with a small molecule

Summary for 5IWD

• Entry DOI: 10.2210/pdb5iwd/pdb
• Related: 1T6L 1YYP 5IXA
• Descriptor: DNA polymerase processivity factor, 5-methylidene-3-(methylsulfanyl)-2-benzothiophen-4(5H)-one (3 entities in total)
• Functional Keywords: covalent inhibitor, hcmv pol accessory subunit, protein-protein interaction, human cytomegalovirus, dna polymerase, processivity factor, replication-replication inhibitor complex, replication/replication inhibitor
• Biological source: Human cytomegalovirus (strain AD169) (HHV-5)
• Total number of polymer chains: 1
• Total formula weight: 33215.39

Authors

Chen, H.,Coen, D.M.,Hogle, J.M.,Filman, D.J. (deposition date: 2016-03-22, release date: 2016-11-30, Last modification date: 2019-12-11)

• Primary citation: Chen, H.,Coseno, M.,Ficarro, S.B.,Mansueto, M.S.,Komazin-Meredith, G.,Boissel, S.,Filman, D.J.,Marto, J.A.,Hogle, J.M.,Coen, D.M.; A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions.; ACS Infect Dis, 3:112-118, 2017; PubMed: 28183184; DOI: 10.1021/acsinfecdis.6b00079

Experimental method