5IWC
Mycobacterium tuberculosis CysM in complex with the Urea-scaffold inhibitor 3 [4-(3-([1,1'-Biphenyl]-3-yl)ureido)-2-hydroxybenzoic acid]
Summary for 5IWC
Entry DOI | 10.2210/pdb5iwc/pdb |
Related | 3DKI 3FGP |
Descriptor | O-phosphoserine sulfhydrylase, PYRIDOXAL-5'-PHOSPHATE, 4-{[([1,1'-biphenyl]-3-yl)carbamoyl]amino}-2-hydroxybenzoic acid, ... (4 entities in total) |
Functional Keywords | mycobacterium tuberculosis, cysteine biosynthesis, sulphur metabolism, inhibitor, lyase, transferase |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Total number of polymer chains | 2 |
Total formula weight | 70639.22 |
Authors | Schnell, R.,Maric, S.,Lindqvist, Y.,Schneider, G. (deposition date: 2016-03-22, release date: 2016-08-17, Last modification date: 2024-01-10) |
Primary citation | Brunner, K.,Maric, S.,Reshma, R.S.,Almqvist, H.,Seashore-Ludlow, B.,Gustavsson, A.L.,Poyraz, O.,Yogeeswari, P.,Lundback, T.,Vallin, M.,Sriram, D.,Schnell, R.,Schneider, G. Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis. J.Med.Chem., 59:6848-6859, 2016 Cited by PubMed: 27379713DOI: 10.1021/acs.jmedchem.6b00674 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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