5IH5
Human Casein Kinase 1 isoform delta (kinase domain) in complex with Epiblastin A
Summary for 5IH5
Entry DOI | 10.2210/pdb5ih5/pdb |
Descriptor | Casein kinase I isoform delta, ZINC ION, 6-(3-chlorophenyl)pteridine-2,4,7-triamine, ... (6 entities in total) |
Functional Keywords | kinase domain, stem cell reprogramming, kinase inhibitor complex, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P48730 |
Total number of polymer chains | 1 |
Total formula weight | 34901.86 |
Authors | Ursu, A.,Illich, D.J.,Takemoto, Y.,Porfetye, A.T.,Zhang, M.,Brockmeyer, A.,Janning, P.,Watanabe, N.,Osada, H.,Vetter, I.R.,Ziegler, S.,Schoeler, H.R.,Waldmann, H. (deposition date: 2016-02-29, release date: 2016-04-13, Last modification date: 2024-01-10) |
Primary citation | Ursu, A.,Illich, D.J.,Takemoto, Y.,Porfetye, A.T.,Zhang, M.,Brockmeyer, A.,Janning, P.,Watanabe, N.,Osada, H.,Vetter, I.R.,Ziegler, S.,Scholer, H.R.,Waldmann, H. Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1. Cell Chem Biol, 23:494-507, 2016 Cited by PubMed: 27049670DOI: 10.1016/j.chembiol.2016.02.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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